Pharmacokinetics of oral zidovudine entrapped in biodegradable nanospheres in rabbits.
نویسندگان
چکیده
The pharmacokinetic profile of oral zidovudine entrapped in a 50:50 polyactide-coglycolide matrix (nanospheres) was compared to those of standard oral and parenteral zidovudine formulations in rabbits. The bioavailability of zidovudine nanospheres at 50 mg/kg of body weight was 76%, and this dose achieved prolonged exposure to zidovudine compared to standard formulations without an increase in the drug's peak concentration.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 43 4 شماره
صفحات -
تاریخ انتشار 1999